Reply To: Is Prestone antifreeze really safe to mix with any color? › Forums › Mechanic & Workshop Advice › Is Prestone antifreeze really safe to mix with any color? May 12, 2025 at 7:06 pm #1237 John Best to use what’s recommended for your specific car. If it’s roadside repair or on a car you don’t really care about, then use whatever you finds at the parts store.